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9h – 12h | Easy ISI 01 On-site Capacity Building Auditorium Centro Administrativo Vinicius Fonseca | Digital Transformation in the Biopharmaceutical Industry |
Easy ISI 02 Online | Artificial Intelligence and diagnostic tools: Challenges for application in the Unified Health System (SUS) | |
13h – 16h | Easy ISI 03 On-site Capacity Building Auditorium Centro Administrativo Vinicius Fonseca | Exploring Advanced Therapies: From conception to clinical practice |
Easy ISI 04 Online | Adjuvants for human use and their different applications | |
9h30 – 11h | Visit Technological Vaccine Complex and Castelo Mourisco | Upon registration |
14h30 – 16h | Visit Technological Vaccine Complex and Castelo Mourisco | Upon registration |
13h43 – 16h43 | WS G20 Auditorium 5th floor – Centro Administrativo Vinicius Fonseca | Guests of the Bio-Manguinhos’ Board |
| 8h – 9h | Welcome coffee & Credentials Science talks 1: Opening of the poster exhibition |
| 9h – 9h20 | Oral presentation 1: VAC-02 – Subjects with respiratory allergy experience distinct adverse effects with COVID-19 vaccines – Laura Alves Ribeiro Oliveira Oral presentation 2: ORT-01 – Investigation of recombinant SARS-CoV-2 nucleocapsid protein thermal properties and its nucleic acid interaction – Luanna Elisa Liebscher Vidal |
| 9h20 – 10h20 | WED-1
Preparedness for the future epidemics: surveillance and scientific & technological development
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| 10h20 – 11h | Science talks 2 – Poster session (exhibition + pitchs) / Coffee break Poster pitch 1: VAC-06 – Immunita-001: Cross-sectional study of immunogenicity, safety and infection by SARS-CoV-2 in adults vaccinated with the inactivated virus vaccine (CoronaVac) in a two-dose protocol and heterologous booster doses – Sarah Vieira Contin Gomes Poster pitch 2: VAC-07 – Cellular response in severe adverse events after COVID-19 vaccination – Felipe Soares Coelho Poster pitch 3: ORT-05 – Spatial-temporal patterns in biologic prescriptions for inflammatory bowel diseases in the public healthcare system in Brazil – Caroline Tianeze de Castro Poster pitch 4: ORT-08 – Correlation between detection of viral gastroenteritis and climatic factors in the Northwest Am.azon región – Nathalia Alves Araujo de Almeida |
| 11h – 12h | WED-2
Strenghtening regional production facilities as a solution to the Global South emergent vaccine demands – Speaker: Rajinder Suri / DCVMN*
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| 12h – 13h30 | Science talks 3 – Poster session (exhibition + pitchs) / Lunch box Poster pitch 5: BIO-06 – Evaluation of sporicidal activity of 2%peracetic acid against filamentous fungus strains for contamination control strategy in a pharmaceutical industry – Amanda Silva Costa Poster pitch 6: ORT-07 – FUT2 gene profile of children with acute gastroenteritis, HBGA non-secretors living in the Northwest Amazon region, and association with rotavirus A and norovirus infection – Mauro França da Silva Poster pitch 7: ORT-02 – Evaluation of Fourier-Transform Infrared Spectroscopy as a rapid method to type Stenotrophomonas maltophilia strains isolated from pharmaceutical industry – Paula Araujo de Souza Poster pitch 8: ORT-15 – Comparison between different VITEK® 2 and MALDI Biotyper® for the identification of Bacillus subtilis group – Laís dos Santos Oliveira Poster pitch 9: ORT-10 – Antimicrobial resistance profile and aggregation capacity evaluation of Burkholderia cepacia complex strains isolated in a pharmaceutical facility – Francisca Letícia de Sousa Sales Poster pitch 10: MAN-03 – Interchangeability of Adalimumab originator and biosimilars in Brazil: real-life evidence opportunity – Mariana Jorge de Queiroz Poster pitch 11: MAN-02 – Regulatory Intelligence (RI) applied to the registration and post-variation of Bio-Manguinhos vaccines and biopharmaceuticals – Celina Vieira da Cunha Guedes Alvarenga Poster pitch 12: MAN-04 – Implementation of the Lead Time methodology for managing the analysis of pharmaceutical inputs in Quality Control – Ana Paula Roque da Silva |
| 13h30 – 14h10 | WED-3
Satellite symposium – Sanofi
Main aspects of production and quality of hexavalent vaccines and experience of implementing acellular vaccines in public programs in Latin America
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| 14h10 – 15h10 | WED-4
The Brazilian Economic and Industrial Complex: How to Achieve Maturity and Self-Sufficiency?
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| 15h10 – 15h30 | Oral presentation 3: VAC-03 – Safety and reactogenicity of covid-19 (Recombinant) vaccine doses administered in 4-, 8- or 12-weeks interval between the first two doses – Ewerton Alves Portela dos Santos Oral presentation 4: MAN-01 – Building A Healthy Future: Health Needs And Technological Horizons In Immunobiologicals – Julianna do Nascimento e Silva Varela |
| 15h30 – 17h | GRAND Opening
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| 17h – 19h | Book launch and autograph session – Tratado Brasileiro de Biotecnologia em Saúde – da bancada ao leito” Science talks 4 – Poster session (exhibition + pitchs) Poster pitch 13: IVD-04 – Design of a new optimized VLP as a positive control of molecular diagnostic kits – Alexandre Rodrigues Calazans Poster pitch 14: IVD-06 – Establishing proof-of-concept for multiplex lateral flow assay to congenital and perinatal infections – Ana Paula dos Santos Poster pitch 15: IVD-15 – Development of a new multiplex platform for detection and screening for virus-caused exanthematic diseases – Pedro Henrique Cardoso Poster pitch 16: IVD-14 – Extending the Shelf-Life of Protein A Gold conjugate for Rapid Syphilis Testing: A Comprehensive Stability Analysis – Giselle Santana de Oliveira Poster pitch 17: IVD-05 – Development and Optimization of Immunological Assay for Evaluation of FITC Immunoconjugates – Marcelle Mello Poster pitch 18: IVD-10 – Assessment of coinfection by Ehrlichia canis and Babesia canis in a Canine Visceral Leishmaniasis serological panel – Carlos Renato Calvet da Silva |
| 8h – 9h | Science talks 5 – Poster session (exhibition+ pitchs) / Welcome coffee Poster pitch 19: BIO-16 – Sustainable compendial grade GMP detergent substitutes for Triton™ X-100 in bioprocessing applications – Letícia Paifer Marques Poster pitch 20: BIO-11 – Characterization of anti-PD-1 biosimilar monoclonal antibody candidates using established methodologies – Thayane Aparecida Alves de Araujo Poster pitch 21: BIO-09 – Structural modeling of two anti-Acinetobacter baumannii monoclonal antibodies and the target surface protein – Laianne Dias Inácio Poster pitch 22: IVD-08 – Evaluation of molecular assays for the detection of respiratory viruses with a view to structuring the national Wastewater-based epidemiology program – Lara Corrêa Umpierre Henriques |
| 9h – 9h20 | Oral presentation 5: IVD-01 – Respiratory Virus Panel 1 (VR1) and Respiratory Virus Panel 2 (VR2) Bio-Manguinhos Molecular Typing Assay: tool for discriminatory diagnosis of respiratory infections – Marisa de Oliveira Ribeiro Oral presentation 6: IVD-03 – Assessment of the activity of the anti-PBP2a monoclonal antibody from methicillin-resistant Staphylococcus aureus (MRSA) against Enterococcus spp. – Julia Hamam de Lucca Teixeira |
| 9h20 – 10h20 | 
THU-1Foundations for translational research and partnerships to accelerate the technological development of biologic products
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| 10h20 – 11h | Science talks 6 – Poster session (exhibition + pitchs) / Coffee break Poster pitch 23: ORT-09 – Laboratory diagnosis of human parvovirus B19 infection in acute febrile illnesses in a malaria-endemic area on the border of Brazil and French Guiana – Ester dos Santos Motta Poster pitch 24: VAC-10 – Peptides for a polyeptide anti-leishmanial vaccine – Prisciliana Jesus de Oliveira Poster pitch 25: VAC-08 – Downstream establishment of the chimeric live-attenuated zika virus vaccine – Stephanie Almeida da Silva Poster pitch 26: ORT-04 – Exploring the Interplay of CLEC5A and Zika Virus: In Silico and In Vitro Investigations – Ryann de Souza Nascimento |
| 11h – 12h | THU-2
Immunobiological development – how to overcome the valley of death: strategies and technologies
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| 12h – 12h40 | THU – 3 Satellite symposium – Promega Lumit™️: A platform for development of rapid and sensitive methods for analyte detection – Juliano Alves, Promega Corporation Plant and Microalgae Extracellular Vesicles as Carriers of RNA-based Therapeutics – Lionel Navarro, IBENS Chair: Marco Alberto Medeiros, Fiocruz/Bio-Manguinhos |
| 12h40 – 14h10 | Science talks 7 – Poster session (exhibition + pitchs) / Lunch box Poster pitch 27: ORT-06 – Human papillomavirus DNA versus Pap smear screening test in women living with human immunodeficiency virus – Milena Siqueira Pereira Poster pitch 28: VAC-09 – Human Papillomavirus vaccination safety: signal detection from vaccine pharmacovigilance, Brazil, 2013-2022 – Mateus de Paula von Glehn Poster pitch 29: ORT-18 – Molecular epidemiology of Human Papillomavirus – Rachel Siqueira de Queiroz Simoes Poster pitch 30: BIO-07 – Upstream optimization of recombinant L-asparaginase production in E. coli for the treatment of Acute Lymphoblastic Leukemia – Gabriela de Assis Ferreira Poster pitch 31: ORT-11 – Generation of allogeneic 19BBz CAR-T using CRISPRGeneration of allogeneic 19BBz CAR-T using CRISPR – Eduardo Mannarino Correia Poster pitch 32: BIO-08 – Optimizing sample preparation and nLC-MS/MS for mAB characterization – Rodrigo Soares Caldeira Brant Poster pitch 33: BIO-12 – Obtainment and characterization of TIM-3_ECD-FC in HEK293-T cells as an antigen for the selection of antibodies for antitumor immunotherapy – Marielly Câmara Rocha Poster pitch 34: BIO-03 – Evaluation of the affinity between single-chain M971 antibody fragments and the CD22 membrane glycoprotein for a CAR-T cell – Alice Soares de Queiroz |
| 14h10 – 15h10 | THU – 4
Accelerated biotech development – key points that have led Korea and China to become global biomanufacturing hubs, and what lessons can be useful for the Brazilian national system for ST&I
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| 15h10 – 15h30 | Oral presentation 7: BIO-02 – Anti-CAIX CAR T cells in the treatment of renal cell carcinoma patient-derived xenografts – Najla Santos Pacheco de Campos Oral presentation 8: BIO-01 – Efficient large-scale point-of-care production of affordable Anti-CD19 CAR-T cells for leukemia immunotherapy – Leonardo Ribeiro Batista Silva |
| 15h30 – 17h | THU – 5
Advanced therapy in Public Health Unified System (SUS) – technologies and access
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| 8h – 9h | Science talks 8 – Poster session (exhibition) / Welcome coffee Poster pitch 35: VAC-05 – Design of a global multiepitope orthohantavirus vaccine: An Immunoinformatics Approach – Silvia da Silva Fontes Poster pitch 36: IVD-07 – Development and standardization of the PAN–FLAVI assay for the detection of flaviviruses with epidemiological importance in Brazil – Anielly ferreira de Brito Poster pitch 37: IVD-09 – Adaptation and evaluation of point-of-care tests for infectious diseases in the telediagnosis system in Pernambuco – UBS – Wagner José Tenório dos Santos Poster pitch 38: IVD-12 – Kit Molecular ZC_D Tipagem Bio-Manguinhos: arbovirus discriminatory assay in CSF simples – Beatriz Vasconcello de Souza Barreto |
| 9h – 9h20 | Oral presentation 9: IVD-02 – Breaking barriers in HTLV-1 diagnosis: VHH ANTI-P24 antibodies for the construction of efficient optical and electrochemical biosensors – Sibele Andrade Roberto Oral presentation 10: VAC-01 – Type I interferon innate errors causing severe adverse events following yellow fever vaccination: a family-based case study – Tamiris Azamor da Costa Barros |
| 9h20 – 10h20 | FRI-1
Arboviruses in Brazil: political and technological challenges for the fight against Dengue
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| 10h20 – 11h | Science talks 9 – Poster session (exhibition + pitchs) / Coffee break Poster pitch 39: IVD-13 – Comparing Blue and Red Gold Nanoparticles in Protein A Bioconjugation for Rapid Diagnostic Tests – Gabriel Mustafá Misirli Poster pitch 40: ORT-17 – Continuous Flow Synthesis of Monodisperse Gold Nanoparticles – Waldemir de Castro Silveira Poster pitch 41: VAC-04 – Assessing mRNA Integrity using Capillary Electrophoresis: Insights into Scientific Parameters – Raysa Silva de Souza Poster pitch 42: ORT-13 – Identification of isolates from an immunobiological industry: comparison between VITEK®2, MALDI-TOF MS and 16S rRNA gene sequencing – Maria Luiza Soares de Souza |
| 11h – 12h | FRI-2
RNA based solutions -The infinite possibilities in biotechnology
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| 12h – 13h30 | Science talks 10 – Poster session (exhibition + pitchs) / Lunch box Poster pitch 43: ORT-12 – Influence of carbonic anhydrase IX and Cyclooxygenase-2 on Immune Checkpoint – Renata Schmieder Pivetta Poster pitch 44: BIO-05 – Development of a peptide mapping protocol with post-translational modifications detection for the recombinant human erythropoietin by LC-MS/MS-based proteomics – Jose Roberto Aparecido dos Santos-Pinto Poster pitch 45: – BIO-10 – Consensus serineprotease toxin design as antigen and cross-immunization combined strategy for generation of broadly binding antibodies – Daniel Alexandre de Souza Poster pitch 46: IVD-11 – Comparison of two forms of a multi-epitope protein, DxCruziV3, for the development of an ELISA-based diagnostic test for Chagas disease – Juliana Toledo Nascimento Poster pitch 47: ORT-19 – Neurofilament light chain as biomarkers for therapeutic monitoring in patients with Relapsing remitting Multiple Sclerosis – Larissa Araujo Duarte Poster pitch 48: ORT-03 – Humoral immunological status after heterologous boosts with COVID -19 vaccines: neutralizing antibodies and IgG avidity against ancestral or variants of SARS-CoV-2 – Brenda de Moura Dias Poster pitch 49: ORT-14 – Neutralizing antibody Levels against Wuhan Strain and the Omicron Variant of SARS-CoV-2 in patients with COVID-19 Disease – Ingrid Siciliano Horbach Poster pitch 50: BIO-04 – Surveillance of influenza viruses with reduced susceptibility to antivirals in Brazil during the COVID-19 pandemic – Thiago das Chagas Sousa |
| 13h30 – 14h30 | FRI-3
Health agenda at the G20 2024 in Rio de Janeiro – systematic actions to focus on one health solutions
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| 14h30 – 15h20 | FRI – 4 Vaccines for 2050 – The next frontiers in Biotechnology Keynote speaker: Rino Rappuoli, Biotecnopolo di Siena Foundation Chair: Akira Homma, Fiocruz/Bio-Manguinhos |
| 15h20 – 16h30 | FRI-5
The front lines of the fight against a global pandemic – The Oxford coronavírus vaccine
Keynote speaker: Sarah Gilbert, Oxford University*
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| 16h30 – 17h | Award ceremony |
| 17h – 19h | Final social gathering |
