– Guided visit to the Museu da Vida and Fiocruz Castle
– Guided visit to Bio-Manguinhos’ vaccine and biopharmaceuticals production site
11:40 – 12:10 – Poster pitch
FROM INFECTIOUS DISEASES TO CANCER – NEW THERAPEUTIC APPROACHES
• ORT-02 – Improvement CAR-T cell therapy with ultra-fast protocol and IL-15 membrane bound addition, Luiza de Macedo Abdo, INCa
• ORT-03 – Evaluation of a betullinic acid nanosystem for cancer therapy, Natália Pereira da Rocha, Fiocruz
• ORT-08 – Synthesis of polymeric nanoparticles of a high potency second generation isoniazid derivative aiming tuberculosis treatment via direct delivery to the lung, Frederico Silva Castelo Branco, Fiocruz/Farmanguinhos
12:20 – 12:50 – Poster pitch
BIOPHARMACEUTICALS AND CANCER
• ORT-07 – Anti-her2 CAR-T cells evaluation in a ovarian tumor preclinical model, Emmanuel Arthur Albuquerque Aragao, INCa
• BIO-04 – Structural modeling and design of scFv fragments from the antineoplastic antibody Brontictuzumab for enhanced binding to Notch1 NRR region, Aline de Oliveira Albuquerque, Fiocruz Ceará
• BIO-08 – Regulation of the epigenetic machinery in pancreatic cancer, Ricardo Alberto Chiong Zevallos, USP
Biopharmaceuticals encoded by DNA and RNA
• CART Cells to treat cardiac injuries using mRNA, Joel Rurik, University of Pensylvannia*
• Next generation lipid nanoparticles technology for extrahepatic delivery of RNA molecules, Jayesh Kulkarn, NanoVation
• Revolutionizing Antibody Discovery with Single-Cell Analysis, James Crowe, Vanderbilt Vaccine Center
Chair: Patricia Neves, Bio-Manguinhos
Poster Oral Presentation 3 (BIO)
• BIO-01 – Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells, Najla Santos Pacheco de Campos, Universidade Federal do ABC
Poster Oral Presentation 4 (MAN)
• MAN-01 – Project For the Recovery of High Vaccination Coverage: innovation in structuring actions to promote vaccination at the local level, Isabel Cristina Alencar De Azevedo, Fiocruz/Bio-Manguinhos
14:40 – 15:10 Poster pitch – NEW THERAPY APPROACHES
• BIO-03 – Development and Characterization of Anti-VLA4 Monoclonal Antibody as a Potential Biopharmaceutical for the Treatment of Multiple Sclerosis, Vitória Fernandes de Castro, Fiocruz/Bio-Manguinhos
• VAC-10 – Safety and immunogenicity of the anti-cocaine vaccine UFMG-VAC-V4N2 in a non-human primate model, Raissa Lima Gonçalves Pereira, UFMG
• BIO-05 – CLEC5A expression can be triggered by spike glycoprotein and may be a potential target for COVID-19 therapy, Thiago Lazari Machado, Fiocruz/Bio-Manguinhos
Management of Biotech Development and Production in the 4th Industrial Revolution
•First steps on the journey to the future of the productive sector, Igor Calvet, ABDI*
•4th Industrial Revolution in Biotech industry, Marcio Freitas, Aché
•Applications of 4.0 solutions in the pharmaceutical industry, Fabricio Costa, Deloitte*
•4.0 platform for the new Bio-Manguinhos plant, Fernando Serva Cavalcanti Leite, Bio-Manguinhos*
Chair: Luiz Alberto Lima*, Bio-Manguinhos
