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Poster pitch 1: VAC-06 - Immunita-001: Cross-sectional study of immunogenicity, safety and infection by SARS-CoV-2 in adults vaccinated with the inactivated virus vaccine (CoronaVac) in a two-dose protocol and heterologous booster doses
Sarah Vieira Contin Gomes
Poster pitch 2: VAC-07 - Cellular response in severe adverse events after COVID-19 vaccination
Felipe Soares Coelho
Poster pitch 3: ORT-05 - Spatial-temporal patterns in biologic prescriptions for inflammatory bowel diseases in the public healthcare system in Brazil
Caroline Tianeze de Castro
Poster pitch 4: ORT-08 - Correlation between detection of viral gastroenteritis and climatic factors in the Northwest Am.azon región
Nathalia Alves Araujo de Almeida
11:00 - 12:00
WED-2 - Strenghtening regional production facilities as a solution to the Global South emergent vaccine demands
Chair:
Mauricio Zuma, Bio-Manguinhos / Fiocruz*
Speaker:
Rajinder Suri / DCVMN*
Discussants:
Adriansjah Azhari, Biofarma; Tiago Rocca, Butantan*; Venkatraman Sivaramakrishnan, BharatBiotech; Rachel Park, EuBiologics; Sunil Gairola, Serum Institute of India*; Andrew Wong, Walvax; Fernando Lobos, Sinergium Biotech
Poster pitch 5: BIO-06 - Evaluation of sporicidal activity of 2%peracetic acid against filamentous fungus strains for contamination control strategy in a pharmaceutical industry
Amanda Silva Costa
Poster pitch 6: ORT-07 - FUT2 gene profile of children with acute gastroenteritis, HBGA non-secretors living in the Northwest Amazon region, and association with rotavirus A and norovirus infection
Mauro França da Silva
Poster pitch 7: ORT-02 - Evaluation of Fourier-Transform Infrared Spectroscopy as a rapid method to type Stenotrophomonas maltophilia strains isolated from pharmaceutical industry
Paula Araujo de Souza
Poster pitch 8: ORT-15 - Comparison between different VITEK® 2 and MALDI Biotyper® for the identification of Bacillus subtilis group
Laís dos Santos Oliveira
Poster pitch 9: ORT-10 - Antimicrobial resistance profile and aggregation capacity evaluation of Burkholderia cepacia complex strains isolated in a pharmaceutical facility
Francisca Letícia de Sousa Sales
Poster pitch 10: MAN-03 - Interchangeability of Adalimumab originator and biosimilars in Brazil: real-life evidence opportunity
Mariana Jorge de Queiroz
Poster pitch 11: MAN-02 - Regulatory Intelligence (RI) applied to the registration and post-variation of Bio-Manguinhos vaccines and biopharmaceuticals
Celina Vieira da Cunha Guedes Alvarenga
Poster pitch 12: MAN-04 - Implementation of the Lead Time methodology for managing the analysis of pharmaceutical inputs in Quality Control
Ana Paula Roque da Silva
13:30 - 14:10
WED-3 - Satellite symposium - Sanofi
Main aspects of production and quality of hexavalent vaccines and experience of implementing acellular vaccines in public programs in Latin America
Chair: Dr José Cássio de Moraes, São Paulo Medical School
Presentations: Main aspects of acellular Vaccines´ Production and Quality
Dr Cesar Mascareñas, Sanofi
Experience of acellular vaccines` introduction in public programs in Latin America
Dra María Luisa Ávila Aguero, University of Costa Rica
14:10 - 15:10
WED-4 - The Brazilian Economic and Industrial Complex: How to Achieve Maturity and Self-Sufficiency?
Chair:
Carlos Gadelha, SECTICS / Brazilian MoH *
Discussants:
Artur Couto, Bio-Manguinhos/Fiocruz; Esper Georges Kallás, Butantan; Luiz Marinho, ALFOB; Odilon José da Costa Filho, Abifina
Gestão
15:10 - 15:30
Oral presentation 3: VAC-03 - Safety and reactogenicity of covid-19 (Recombinant) vaccine doses administered in 4-, 8- or 12-weeks interval between the first two doses - Ewerton Alves Portela dos Santos
Oral presentation 4: MAN-01 - Building A Healthy Future: Health Needs And Technological Horizons In Immunobiologicals - Julianna do Nascimento e Silva Varela
15:30 - 17:00
GRAND Opening
Authorities:
- Carlos Gadelha, SECTICS / Brazilian MoH
- Mario Santos Moreira, Fiocruz
- Tedros Adhanom Ghebreyesus, WHO**
- Jarbas Barbosa** and Socorro Gross, PAHO
- Carlos Ivan Simonsen Leal , FGV
- Maurício Zuma, Bio-Manguinhos / Fiocruz
- Akira Homma, Fiocruz/Bio-Manguinhos - 8th ISI Scientific and Technological Committee
17:00 - 19:00
Book launch and autograph session – Tratado Brasileiro de Biotecnologia em Saúde – da bancada ao leito”
Poster pitch 19: BIO-16 - Sustainable compendial grade GMP detergent substitutes for Triton™ X-100 in bioprocessing applications
Letícia Paifer Marques
Poster pitch 20: BIO-11 - Characterization of anti-PD-1 biosimilar monoclonal antibody candidates using established methodologies
Thayane Aparecida Alves de Araujo
Poster pitch 21: BIO-09 - Structural modeling of two anti-Acinetobacter baumannii monoclonal antibodies and the target surface protein
Laianne Dias Inácio
Poster pitch 22: IVD-08 - Evaluation of molecular assays for the detection of respiratory viruses with a view to structuring the national Wastewater-based epidemiology program
Lara Corrêa Umpierre Henriques
09:00 - 09:20
Oral presentation 5: IVD-01 - Respiratory Virus Panel 1 (VR1) and Respiratory Virus Panel 2 (VR2) Bio-Manguinhos Molecular Typing Assay: tool for discriminatory diagnosis of respiratory infections - Marisa de Oliveira Ribeiro
Oral presentation 6: IVD-03 - Assessment of the activity of the anti-PBP2a monoclonal antibody from methicillin-resistant Staphylococcus aureus (MRSA) against Enterococcus spp. - Julia Hamam de Lucca Teixeira
09:20 - 10:20
THU-1 - InnovationHub
Foundations for translational research and partnerships to accelerate the technological development of biologic products
Chair:
Leda Castilho, UFRJ*
Presentations: Brazilian National Center for Research in Energy and Materials (CNPEM): cutting-edge Science to tackle Global Health Challenges
Sandra Dias – CNPEM/LMBIO
Prototype plant
Ricardo de Godoi Mattos Ferreira, Bio-Manguinhos / Fiocruz
Infrastructure to accelerate Innovation in vacines
Raches Ella, Bharat Biotec*
Poster pitch 23: ORT-09 - Laboratory diagnosis of human parvovirus B19 infection in acute febrile illnesses in a malaria-endemic area on the border of Brazil and French Guiana
Ester dos Santos Motta
Poster pitch 24: VAC-10 - Peptides for a polyeptide anti-leishmanial vaccine
Prisciliana Jesus de Oliveira
Poster pitch 25: VAC-08 – Downstream establishment of the chimeric live-attenuated zika virus vaccine
Stephanie Almeida da Silva
Poster pitch 26: ORT-04 - Exploring the Interplay of CLEC5A and Zika Virus: In Silico and In Vitro Investigations
Ryann de Souza Nascimento
11:00 - 12:00
THU-2 - Immunobiological development - how to overcome the valley of death: strategies and technologies
Chair:
Ricardo de Godoi, Bio-Manguinhos / Fiocruz
Presentations: Next-generation virus production: from clone, to AMBR, to perfusion and very high virus yield
Yvonne Genzel, Max-Planck-Institute, Germany*
Vaccines for a safer world - the pitfalls in the development of vaccines for neglected diseases
Hayato Urabe, GHIT*
Managing innovation in human health biotechnology startups in Brazil: Evidence and lessons learned
Paulo Negreiros Figueiredo, FGV*
Vacinas
12:00 - 12:40
THU-3 - Satellite symposium - Promega
Chair:
Marco Alberto Medeiros, Bio-Manguinhos / Fiocruz
Presentations: Lumit™️: Uma plataforma para o desenvolvimento de métodos rápidos e sensíveis de detecção de analitos
Juliano Alves, Promega Corporation
Plant and Microalgae Extracellular Vesicles as Carriers of RNA-based Therapeutics
Lionel Navarro, IBENS
Poster pitch 27: ORT-06 - Human papillomavirus DNA versus Pap smear screening test in women living with human immunodeficiency virus
Milena Siqueira Pereira
Poster pitch 28: VAC-09 - Human Papillomavirus vaccination safety: signal detection from vaccine pharmacovigilance, Brazil, 2013-2022
Mateus de Paula von Glehn
Poster pitch 29: ORT-18 - Molecular epidemiology of Human Papillomavirus
Rachel Siqueira de Queiroz Simoes
Poster pitch 30: BIO-07 - Upstream optimization of recombinant L-asparaginase production in E. coli for the treatment of Acute Lymphoblastic Leukemia
Gabriela de Assis Ferreira
Poster pitch 31: ORT-11 - Generation of allogeneic 19BBz CAR-T using CRISPR
Eduardo Mannarino Correia
Poster pitch 32: BIO-08 - Optimizing sample preparation and nLC-MS/MS for mAB characterization
Rodrigo Soares Caldeira Brant
Poster pitch 33: BIO-12 - Obtainment and characterization of TIM-3_ECD-FC in HEK293-T cells as an antigen for the selection of antibodies for antitumor immunotherapy
Marielly Câmara Rocha
Poster pitch 34: BIO-03 - Evaluation of the affinity between single-chain M971 antibody fragments and the CD22 membrane glycoprotein for a CAR-T cell
Alice Soares de Queiroz
14:10 - 15:10
THU-4 - Accelerated biotech development – key points that have led Korea and China to become global biomanufacturing hubs, and what lessons can be useful for the Brazilian national system for ST&I
Chair:
Gustavo Mendes, Butantan
Presentations: Korean approach sudy case
Christiane Gerke, IVI
China approach study case
George Fu Gao, Chinese Academy of Sciences*
Biofármacos
Vacinas
15:10 - 15:30
Oral presentation 7: BIO-02 - Anti-CAIX CAR T cells in the treatment of renal cell carcinoma patient-derived xenografts - Najla Santos Pacheco de Campos
Oral presentation 8: BIO-01 - Efficient large-scale point-of-care production of affordable Anti-CD19 CAR-T cells for leukemia immunotherapy - Leonardo Ribeiro Batista Silva
15:30 - 17:00
THU-5 - Advanced therapy in Public Health Unified System (SUS) - technologies and access
Chair:
Antonio Carlos Campos de Carvalho, Fiocruz
Presentations: AAV - based vectors as a platform for treating diseases
James Wilson, UPENN*
Lentiviral vector-based solutions to treat human diseases
Boro Dropulic, Caring Cross
Gene therapy- based approaches to treat patients in SUS
Martín Bonamino, INCa/Fiocruz
Discussants:
Marco Krieger, Fiocruz*
Biofármacos
08:00 - 09:00
Science talks 8 – Poster session (exhibition)
Welcome coffee
Poster pitch 35: VAC-05 – Design of a global multiepitope orthohantavirus vaccine: An Immunoinformatics Approach
Silvia da Silva Fontes
Poster pitch 36: IVD-07 - Development and standardization of the PAN–FLAVI assay for the detection of flaviviruses with epidemiological importance in Brazil
Anielly Ferreira de Brito
Poster pitch 37: IVD-09 - Adaptation and evaluation of point-of-care tests for infectious diseases in the telediagnosis system in Pernambuco – UBS
Oral presentation 9: IVD-02 - Breaking barriers in HTLV-1 diagnosis: VHH ANTI-P24 antibodies for the construction of efficient optical and electrochemical biosensors - Sibele Andrade Roberto
Oral presentation 10: VAC-01 - Type I interferon innate errors causing severe adverse events following yellow fever vaccination: a family-based case study - Tamiris Azamor da Costa Barros
09:20 - 10:20
FRI-1 - Arboviruses in Brazil: political and technological challenges for the fight against Dengue
Chair:
Margareth Dalcolmo, Fiocruz
Presentations: Vaccination policy against Dengue
Eder Gatti, CGPNI - MoH
Wolbachia method: a powerful strategy for controlling arboviruses
Karlos Diogo Chalegre, Fiocruz
Clinical trials of a Dengue vaccine
Fernanda Castro Boulos, Butantan
Poster pitch 41: VAC-04 - Assessing mRNA Integrity using Capillary Electrophoresis: Insights into Scientific Parameters
Raysa Silva de Souza
Poster pitch 42: ORT-13 - Identification of isolates from an immunobiological industry: comparison between VITEK®2, MALDI-TOF MS and 16S rRNA gene sequencing
Maria Luiza Soares de Souza
11:00 - 12:00
FRI-2 - RNA based solutions -The infinite possibilities in biotechnology
Poster pitch 43: ORT-12 - Influence of carbonic anhydrase IX and Cyclooxygenase-2 on Immune Checkpoint
Renata Schmieder Pivetta
Poster pitch 44: BIO-05 - Development of a peptide mapping protocol with post-translational modifications detection for the recombinant human erythropoietin by LC-MS/MS-based proteomics
Jose Roberto Aparecido dos Santos-Pinto
Poster pitch 45: BIO-10 - Consensus serine protease toxin design as antigen and cross-immunization combined strategy for generation of broadly binding antibodies
Daniel Alexandre de Souza
Poster pitch 46: IVD-11 - Comparison of two forms of a multi-epitope protein, DxCruziV3, for the development of an ELISA-based diagnostic test for Chagas disease
Juliana Toledo Nascimento
Poster pitch 47: ORT-19 - Neurofilament light chain as biomarkers for therapeutic monitoring in patients with Relapsing remitting Multiple Sclerosis
Larissa Araujo Duarte
Poster pitch 48: ORT-03 - Humoral immunological status after heterologous boosts with COVID-19 vaccines: neutralizing antibodies and IgG avidity against ancestral or variants of SARS-CoV-2
Brenda de Moura Dias
Poster pitch 49: ORT-14 - Neutralizing antibody Levels against Wuhan Strain and the Omicron Variant of SARS-CoV-2 in patients with COVID-19 Disease
Ingrid Siciliano Horbach
Poster pitch 50: BIO-04 - Surveillance of influenza viruses with reduced susceptibility to antivirals in Brazil during the COVID-19 pandemic
Thiago das Chagas Sousa
13:30 - 14:30
FRI-3 - Health agenda at the G20 2024 in Rio de Janeiro - systematic actions to focus on one health solutions
Chair:
Pedro Burger, Fiocruz/CRIS
Presentations: Government agenda
Alexandre Ghisleni, MoH/AISA*
Engagement and innovation agenda
Graziela Ferrero Zucoloto, IPEA – T20
Scientific and academic agenda
Patricia Bozza - Fiocruz and ABC - S20
14:30 - 15:20
FRI-4 - Vaccines for 2050 - The next frontiers in Biotechnology
Chair:
Akira Homma, Bio-Manguinhos / Fiocruz
Keynote speaker:
Rino Rappuoli, Biotecnopolo di Siena Foundation
Vacinas
15:20 - 16:30
FRI-5 - The front lines of the fight against a global pandemic - The Oxford coronavírus vaccine
