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  • 
WHEN
7, 8, 9 and 10 
May 2024

Programação

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  • May 07


  • May 08


  • May 09


  • May 10




  • Digital Transformation in the Biopharmaceutical Industry

    Where
    On-site: Capacity Building Auditorium Centro Administrativo Vinicius Fonseca



  • Artificial Intelligence and diagnostic tools: Challenges for application in the Unified Health System (SUS)

    Where
    Online



  • Exploring Advanced Therapies: From conception to clinical practice

    Where
    On-site: Capacity Building - Auditorium Centro Administrativo Vinicius Fonseca



  • Adjuvants for human use and their different applications

    Where
    Online

  • Upon registration here.
    Where
    Technological Vaccine Complex and Castelo Mourisco

  • Upon registration here.
    Where
    Technological Vaccine Complex and Castelo Mourisco

  • Guests of the Bio-Manguinhos’ Board
    Where
    Auditorium 5th floor - Centro Administrativo Vinicius Fonseca

  • Credentials

    Science talks 1: Opening of the poster exhibition

  • Oral presentation 2: ORT-01 - Investigation of recombinant SARS-CoV-2 nucleocapsid protein thermal properties and its nucleic acid interaction - Luanna Elisa Liebscher Vidal

  • Chair: Julio Croda, Fiocruz*



    Presentations:
    Emergency preparedness and response in Brazil
    Ethel Maciel – MoH/SVS

    The impact of COVID-19 in Africa and lessons for the future
    Christopher Gill, Bill & Melinda Gates Foundation*

    New accelerated technologies for diagnostics, vaccines and treatmens
    Rino Rappuoli, Biotecnopolo di Siena Foundation
    Kits-diagnóstico
    Vacinas

  • Coffee break

    Poster pitch 1: VAC-06 - Immunita-001: Cross-sectional study of immunogenicity, safety and infection by SARS-CoV-2 in adults vaccinated with the inactivated virus vaccine (CoronaVac) in a two-dose protocol and heterologous booster doses
    Sarah Vieira Contin Gomes

    Poster pitch 2: VAC-07 - Cellular response in severe adverse events after COVID-19 vaccination
    Felipe Soares Coelho

    Poster pitch 3: ORT-05 - Spatial-temporal patterns in biologic prescriptions for inflammatory bowel diseases in the public healthcare system in Brazil
    Caroline Tianeze de Castro

    Poster pitch 4: ORT-08 - Correlation between detection of viral gastroenteritis and climatic factors in the Northwest Am.azon región
    Nathalia Alves Araujo de Almeida


  • Chair:
    Mauricio Zuma, Bio-Manguinhos / Fiocruz*

    Speaker:
    Rajinder Suri / DCVMN*

    Discussants:
    Adriansjah Azhari, Biofarma*; Tiago Rocca, Butantan*; Venkatraman Sivaramakrishnan, BharatBiotech*; Rachel Park, EuBiologics*; Sunil Gairola, Serum Institute of India*; Andrew Wong, Walwax*; Fernando Lobos, Sinergium Biotech*
    Vacinas

  • Poster pitch 5: BIO-06 - Evaluation of sporicidal activity of 2%peracetic acid against filamentous fungus strains for contamination control strategy in a pharmaceutical industry
    Amanda Silva Costa

    Poster pitch 6: ORT-07 - FUT2 gene profile of children with acute gastroenteritis, HBGA non-secretors living in the Northwest Amazon region, and association with rotavirus A and norovirus infection
    Mauro França da Silva

    Poster pitch 7: ORT-02 - Evaluation of Fourier-Transform Infrared Spectroscopy as a rapid method to type Stenotrophomonas maltophilia strains isolated from pharmaceutical industry
    Paula Araujo de Souza

    Poster pitch 8: ORT-15 - Comparison between different VITEK® 2 and MALDI Biotyper® for the identification of Bacillus subtilis group
    Laís dos Santos Oliveira

    Poster pitch 9: ORT-10 - Antimicrobial resistance profile and aggregation capacity evaluation of Burkholderia cepacia complex strains isolated in a pharmaceutical facility
    Francisca Letícia de Sousa Sales

    Poster pitch 10: MAN-03 - Interchangeability of Adalimumab originator and biosimilars in Brazil: real-life evidence opportunity
    Mariana Jorge de Queiroz

    Poster pitch 11: MAN-02 - Regulatory Intelligence (RI) applied to the registration and post-variation of Bio-Manguinhos vaccines and biopharmaceuticals
    Celina Vieira da Cunha Guedes Alvarenga

    Poster pitch 12: MAN-04 - Implementation of the Lead Time methodology for managing the analysis of pharmaceutical inputs in Quality Control
    Ana Paula Roque da Silva


  • Main aspects of production and quality of hexavalent vaccines and experience of implementing acellular vaccines in public programs in Latin America

    Chair: Dr José Cássio de Moraes, São Paulo Medical School


    Presentations:
    Main aspects of acellular Vaccines´ Production and Quality
    Dr Cesar Mascareñas, Sanofi

    Experience of acellular vaccines` introduction in public programs in Latin America
    Dra María Luisa Ávila Aguero, University of Costa Rica


  • Chair:
    Carlos Gadelha, SECTICS / Brazilian MoH *


    Discussants:
    Artur Couto, Bio-Manguinhos/Fiocruz*; Esper Georges Kallás, Butantan*; Jorge Mendonça, ALFOB*; Odilon José da Costa Filho, Abifina
    Gestão

  • Oral presentation 4: MAN-01 - Building A Healthy Future: Health Needs And Technological Horizons In Immunobiologicals - Julianna do Nascimento e Silva Varela

  • Coral da Fiocruz

    Chair:
    Akira Homma, Bio-Manguinhos / Fiocruz*


    Authorities:
    - Carlos Gadelha, SECTICS / Brazilian MoH
    - Mario Santos Moreira, Fiocruz*
    - Tedros Adhanom Ghebreyesus, WHO*
    - Jarbas Barbosa* and Socorro Gross, PAHO*
    - Carlos Ivan Simonsen Leal , FGV*
    - Maurício Zuma, Bio-Manguinhos / Fiocruz*



  • Poster pitch 13: IVD-04 - Design of a new optimized VLP as a positive control of molecular diagnostic kits
    Alexandre Rodrigues Calazans

    Poster pitch 14: IVD-06 - Establishing proof-of-concept for multiplex lateral flow assay to congenital and perinatal infections
    Ana Paula dos Santos

    Poster pitch 15: IVD-15 - Development of a new multiplex platform for detection and screening for virus-caused exanthematic diseases
    Pedro Henrique Cardoso

    Poster pitch 16: IVD-14 - Extending the Shelf-Life of Protein A Gold conjugate for Rapid Syphilis Testing: A Comprehensive Stability Analysis
    Giselle Santana de Oliveira

    Poster pitch 17: IVD-05 - Development and Optimization of Immunological Assay for Evaluation of FITC Immunoconjugates
    Marcelle Mello

    Poster pitch 18: IVD-10 - Assessment of coinfection by Ehrlichia canis and Babesia canis in a Canine Visceral Leishmaniasis serological panel
    Carlos Renato Calvet da Silva



    Book launch and autograph session - Biotecnologia



  • Welcome coffee


    Poster pitch 19: BIO-16 - Sustainable compendial grade GMP detergent substitutes for Triton™ X-100 in bioprocessing applications
    Letícia Paifer Marques

    Poster pitch 20: BIO-11 - Characterization of anti-PD-1 biosimilar monoclonal antibody candidates using established methodologies
    Thayane Aparecida Alves de Araujo

    Poster pitch 21: BIO-09 - Structural modeling of two anti-Acinetobacter baumannii monoclonal antibodies and the target surface protein
    Laianne Dias Inácio

    Poster pitch 22: IVD-08 - Evaluation of molecular assays for the detection of respiratory viruses with a view to structuring the national Wastewater-based epidemiology program
    Lara Corrêa Umpierre Henriques


  • Oral presentation 6: IVD-03 - Assessment of the activity of the anti-PBP2a monoclonal antibody from methicillin-resistant Staphylococcus aureus (MRSA) against Enterococcus spp. - Julia Hamam de Lucca Teixeira


  • Foundations for translational research and partnerships to accelerate the technological development of biologic products


    Chair:
    Leda Castilho, UFRJ*


    Presentations:
    Brazilian National Center for Research in Energy and Materials (CNPEM): cutting-edge Science to tackle Global Health Challenges
    Maria Augusta Arruda – CNPEM/LMBIO*

    Prototype plant
    Elaine Teles, Bio-Manguinhos / Fiocruz*

    Infrastructure to accelerate Innovation in vacines
    Raches Ella, Bharat Biotec*

    Biofármacos
    Vacinas

  • Coffee break


    Poster pitch 23: ORT-09 - Laboratory diagnosis of human parvovirus B19 infection in acute febrile illnesses in a malaria-endemic area on the border of Brazil and French Guiana
    Ester dos Santos Motta

    Poster pitch 24: VAC-10 - Peptides for a polyeptide anti-leishmanial vaccine
    Prisciliana Jesus de Oliveira

    Poster pitch 25: VAC-05 - Design of a global multiepitope orthohantavirus vaccine: An Immunoinformatics Approach
    Silvia da Silva Fontes
    Poster pitch 26: ORT-04 - Exploring the Interplay of CLEC5A and Zika Virus: In Silico and In Vitro Investigations
    Ryann de Souza Nascimento


  • Chair:
    Ricardo de Godoi, Bio-Manguinhos / Fiocruz*


    Presentations:
    Next-generation virus production: from clone, to AMBR, to perfusion and very high virus yield
    Yvonne Genzel, Max-Planck-Institute, Germany*

    Vaccines for a safer world - the pitfalls in the development of vaccines for neglected diseases
    Hayato Urabe, GHIT*

    Managing innovation in human health biotechnology startups in Brazil: Evidence and lessons learned
    Paulo Negreiros Figueiredo, FGV*
    Vacinas

  • Lumit™️: Uma plataforma para o desenvolvimento de métodos rápidos e sensíveis de detecção de analitos
    Juliano Alves, Promega Corporation*

  • Lunch box


    Poster pitch 27: ORT-06 - Human papillomavirus DNA versus Pap smear screening test in women living with human immunodeficiency virus
    Milena Siqueira Pereira

    Poster pitch 28: VAC-09 - Human Papillomavirus vaccination safety: signal detection from vaccine pharmacovigilance, Brazil, 2013-2022
    Mateus de Paula von Glehn

    Poster pitch 29: ORT-18 - Molecular epidemiology of Human Papillomavirus
    Rachel Siqueira de Queiroz Simoes

    Poster pitch 30: BIO-07 - Upstream optimization of recombinant L-asparaginase production in E. coli for the treatment of Acute Lymphoblastic Leukemia
    Gabriela de Assis Ferreira

    Poster pitch 31: ORT-11 - Generation of allogeneic 19BBz CAR-T using CRISPR
    Eduardo Mannarino Correia

    Poster pitch 32: BIO-08 - Optimizing sample preparation and nLC-MS/MS for mAB characterization
    Rodrigo Soares Caldeira Brant

    Poster pitch 33: BIO-12 - Obtainment and characterization of TIM-3_ECD-FC in HEK293-T cells as an antigen for the selection of antibodies for antitumor immunotherapy
    Marielly Câmara Rocha

    Poster pitch 34: BIO-03 - Evaluation of the affinity between single-chain M971 antibody fragments and the CD22 membrane glycoprotein for a CAR-T cell
    Alice Soares de Queiroz


  • Chair:
    Gustavo Mendes, Butantan*


    Presentations:
    Korean approach sudy case
    Christiane Gerke, IVI*

    China approach study case
    George Fu Gao, Chinese Academy of Sciences*
    Biofármacos
    Vacinas

  • Oral presentation 8: BIO-01 - Efficient large-scale point-of-care production of affordable Anti-CD19 CAR-T cells for leukemia immunotherapy - Leonardo Ribeiro Batista Silva

  • Chair:
    Antonio Carlos Campos de Carvalho, Fiocruz*


    Presentations:
    AAV - based vectors as a platform for treating diseases
    James Wilson, UPENN*

    Lentiviral vector-based solutions to treat human diseases
    Boro Dropulic, Caring Cross*

    Gene therapy- based approaches to treat patients in SUS
    Martín Bonamino, INCa/Fiocruz*


    Discussants:
    Marco Krieger, Fiocruz*
    Biofármacos


  • Welcome coffee


    Poster pitch 35: VAC-08 - Downstream establishment of the chimeric live-attenuated zika virus vaccine
    Stephanie Almeida da Silva

    Poster pitch 36: IVD-07 - Development and standardization of the PAN–FLAVI assay for the detection of flaviviruses with epidemiological importance in Brazil
    Anielly Ferreira de Brito

    Poster pitch 37: IVD-09 - Adaptation and evaluation of point-of-care tests for infectious diseases in the telediagnosis system in Pernambuco – UBS
    Wagner José Tenório dos Santos

    Poster pitch 38: IVD-12 - Kit Molecular ZC_D Tipagem Bio-Manguinhos: arbovirus discriminatory assay in CSF simples
    Beatriz Vasconcello de Souza Barreto


  • Oral presentation 10: VAC-01 - Type I interferon innate errors causing severe adverse events following yellow fever vaccination: a family-based case study - Tamiris Azamor da Costa Barros

  • Chair:
    Margareth Dalcolmo, Fiocruz*


    Presentations:
    Vaccination policy against Dengue
    Eder Gatti, CGPNI - MoH*

    Wolbachia method: a powerful strategy for controlling arboviruses
    Karlos Diogo Chalegre, Fiocruz*

    Clinical trials of a Dengue vaccine
    Fernanda Castro Boulos, Butantan*
    Gestão
    Vacinas

  • Coffee break


    Poster pitch 39: IVD-13 - Comparing Blue and Red Gold Nanoparticles in Protein A Bioconjugation for Rapid Diagnostic Tests
    Gabriel Mustafá Misirli

    Poster pitch 40: ORT-17 - Continuous Flow Synthesis of Monodisperse Gold Nanoparticles
    Waldemir de Castro Silveira

    Poster pitch 41: VAC-04 - Assessing mRNA Integrity using Capillary Electrophoresis: Insights into Scientific Parameters
    Raysa Silva de Souza

    Poster pitch 42: ORT-13 - Identification of isolates from an immunobiological industry: comparison between VITEK®2, MALDI-TOF MS and 16S rRNA gene sequencing
    Maria Luiza Soares de Souza


  • Chair:
    Milena Botelho Pereira Soares, Senai CIMATEC / Fiocruz-Bahia*


    Presentations:
    mRNA vacines platform
    Patricia Neves, Bio-Manguinhos / Fiocruz*

    RNAi therapeutics: moving from the research to a reality
    Jing-Tao Wu, Alnylam Pharmaceuticals*

    Helper Lipids: Impact on Expression, Immunogenicity, and Stability of Self-Amplifying RNA Lipid Nanoparticle Vaccines
    Beatriz Dias Barbieri, Imperial College London*
    Biofármacos
    Vacinas

  • Lunch box


    Poster pitch 43: ORT-12 - Influence of carbonic anhydrase IX and Cyclooxygenase-2 on Immune Checkpoint
    Renata Schmieder Pivetta

    Poster pitch 44: BIO-05 - Development of a peptide mapping protocol with post-translational modifications detection for the recombinant human erythropoietin by LC-MS/MS-based proteomics
    Jose Roberto Aparecido dos Santos-Pinto

    Poster pitch 45: BIO-10 - Consensus serine protease toxin design as antigen and cross-immunization combined strategy for generation of broadly binding antibodies
    Daniel Alexandre de Souza

    Poster pitch 46: IVD-11 - Comparison of two forms of a multi-epitope protein, DxCruziV3, for the development of an ELISA-based diagnostic test for Chagas disease
    Juliana Toledo Nascimento

    Poster pitch 47: ORT-19 - Neurofilament light chain as biomarkers for therapeutic monitoring in patients with Relapsing remitting Multiple Sclerosis
    Larissa Araujo Duarte

    Poster pitch 48: ORT-03 - Humoral immunological status after heterologous boosts with COVID-19 vaccines: neutralizing antibodies and IgG avidity against ancestral or variants of SARS-CoV-2
    Brenda de Moura Dias

    Poster pitch 49: ORT-14 - Neutralizing antibody Levels against Wuhan Strain and the Omicron Variant of SARS-CoV-2 in patients with COVID-19 Disease
    Ingrid Siciliano Horbach

    Poster pitch 50: BIO-04 - Surveillance of influenza viruses with reduced susceptibility to antivirals in Brazil during the COVID-19 pandemic
    Thiago das Chagas Sousa


  • Chair:
    Pedro Burger, Fiocruz/CRIS*




    Presentations:
    Government agenda
    Alexandre Ghisleni, MoH/AISA

    Engagement and innovation agenda
    Graziela Ferrero Zucoloto, IPEA – T20*

    Scientific and academic agenda
    Patricia Bozza - Fiocruz and ABC - S20*




  • Chair:
    Akira Homma, Bio-Manguinhos / Fiocruz*


    Keynote speaker:
    Rino Rappuoli, Biotecnopolo di Siena Foundation *
    Vacinas

  • Chair:
    Maurício Zuma, Bio-Manguinhos/Fiocruz*


    Keynote speaker:
    Sarah Gilbert, Oxford University*

    Clinical trials of the coronavírus vaccine in Brazil
    Sue Ann Costa Clemmens, Oxford Latam*
    Vacinas